Director Fernando Meirelles (City of God, The Constant Gardener) creates an intensely bleak and unpleasant cinematic experience with Blindness, adapted from José Saramagos novel. Julianne Moore plays the only person who can see in a quarantine facility for the blind. Stricken with a disease that robs them of sight and left to fend for themselves while armed guards and barbed wire keep them from leaving, the newly blind descend into filth and barbarism. Theres a particularly unpleasant rape-and-murder sequence, and the litter-filled hallways and excrement-festooned bathrooms of the facility are smartly, if horrifyingly, conceived. Credit must be given to Meirelles for an uncompromising vision, and the film will definitely stick with youbut it may be too despairing to find an audience.