Multiple locations
Holy guacamole xerocole-y! (Xerocoles are animals adapted to live in the desert, like Tucsonans.) Guadalajara Grill is here for all your chip dippin', margaraita sippin', belt-undoin' and pants unzippin' needs with their titles reigning champs for best salsa and best guacamole. Their menu proclaims that only the finest avocados are selected to be put into their twice-a-day batches, giving the city something to guac about.
Runners up:
2. El Charro Cafe
3. Blanco Tacos + Tequila